The most runs in a Twenty20 International career is 1,100 by Brendon McCullum (b. 27 September 1981, New Zealand) in 40 matches between 17 Feb 2005 and 23 May 2010.

McCullum became the first batsmen to score 1,000 runs in a T20 career, reaching the milestone on 4 May 2010 in a match against Zimbabwe.