The most sixes hit in an innings in a Twenty20 international is 10 by Chris Gayle (b. 21 September 1979, Jamaica) in his 117 (from 57 deliveries) for the West Indies against South Africa in Johannesburg, South Africa on 11 September 2007.

Chris Gayle was born in Kingston, Jamaica and has played first-class cricket for Worcestershire and Kolkata Knight Riders.